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Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis Article

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Engineering 2022, Volume 10, Issue 3,   Pages 174-182 doi: 10.1016/j.eng.2020.08.018

Abstract:

Secondary amyloid A amyloidosis, a lethal complication, is induced when acute or chronic infection coexists with over-secretion of the serum amyloid A 1 (SAA1) protein and deposition in key internal organs. Previously, using the whole-exome sequencing method, we identified a novel deleterious mutation SAA1.2 in rheumatoid arthritis (RA) patients. However, the role of SAA1 in RA pathogenesis and its complications remains unknown. The purpose of this study was to determine the pathogenetic roles of SAA1 protein isoforms in RA progression. We modified an experimental adenovirus infection protocol to introduce SAA1.2 gene alleles into the knee joints of mice and used SAA1.3 and SAA1.5 as controls. Micro-computed tomography analysis was applied to determine changes in bone morphology and density. Immunohistochemical (IHC) analysis, flow cytometry, enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (RT-PCR) were used to investigate disease progression and cytokine alterations in the course of adenoviral SAA-induced knee joint inflammation and bone destruction. We found that the arthritis-inducing effect of SAA1.2 transcription in the knee joints and mutant SAA1 protein secretion in blood resulted in the stimulation of immune responses, leading to CD8+ T cell and pro-inflammatory cytokine elevation, such as interleukin (IL)-6, IL-22, matrix metalloproteinase (MMP)-3, MMP-9, with subsequent synovial inflammation and bone destruction. These findings indicate that SAA1 protein isoforms, particularly SAA1.2, play a significant role in the induction and progression of RA and may have potential value in the early diagnosis and severity prediction of RA.

Keywords： Serum amyloid A 1     Rheumatoid arthritis     Pathogenetic     Intra-articular    

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Networking Architecture and Development Trend of Industrial Internet

Yu Xiaohui, Zhang Hengsheng, Peng Yan, Li Dong

Strategic Study of CAE 2018, Volume 20, Issue 4,   Pages 79-84 doi: 10.15302/J-SSCAE-2018.04.013

Abstract: The intra-factory network is developing in directions of integration, openness, and flexibility.the networking framework of the industrial Internet, and suggests that industrial enterprises build intra-factory

Keywords： intra-factory network     extra-factory network     openness     integration    

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Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation

SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 167-172 doi: 10.1007/s11684-007-0031-5

Abstract: An independent association between acute renal failure (ARF) and intra-abdominal hypertension (IAH) afterIntra-abdominal pressure (IAP) was measured in the first three days after surgery by using the urinary
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Anovel resource optimization scheme for multi-cellOFDMArelay network Article

Ning DU,Fa-sheng LIU

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 8,   Pages 825-833 doi: 10.1631/FITEE.1500294

Abstract: This gives rise to the scenario of intra-cell communication.

Keywords： Intra-cell communication     Two-way relay     Subcarrier assignment     Subcarrier pairing    

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Transmission performance analysisof IR- UWB system in multipath environment

Lin Di,Sha Xuejun ,Wu Xuanli ,Zhang Naitong

Strategic Study of CAE 2009, Volume 11, Issue 2,   Pages 75-81

Abstract: ) analysis of UWB systems with coherent demodulation in the presence of inter- symbol interference, intramodels, which is defined by the IEEE 802.15.3a Task Group, and then through calculating the variance of intraBy analyzing the average multipath interval and comparing BERs with and without intra- symbol interference, the results show that intra- symbol interference should not be neglected.channel environments, the maximum transmission data rate is analyzed by both considering and neglecting intra

Keywords： Ultra- Wideband     intra- symbol multipath interference     inter- symbol interference     multi- userinterference    

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Analyzing the Effect of the Intra-Pixel Position of Small PSFs for Optimizing the PL of Optical Subpixel Article

Haiyang Zhan, Fei Xing, Jingyu Bao, Ting Sun, Zhenzhen Chen, Zheng You, Li Yuan

Engineering 2023, Volume 27, Issue 8,   Pages 140-149 doi: 10.1016/j.eng.2023.03.009

Abstract: which depends on the detected photon count, noise, point spread function (PSF) radius, and PSF’s intra-pixelclearly reported the effects of the first three parameters on the precision limit but have neglected the intra-pixelHere, we develop a localization precision limit analysis framework for revealing the effect of the intra-pixelsmall PSFs, we first derive simplified equations for finding the best precision limit and the best intra-pixel

Keywords： Optical measurement     Subpixel localization     Precision limit optimization     Small point spread functions     Centroiding     Star sensors    

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Title Author Date Type Operation

Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Journal Article

Networking Architecture and Development Trend of Industrial Internet

Yu Xiaohui, Zhang Hengsheng, Peng Yan, Li Dong

Journal Article

Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation

SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei

Journal Article

Anovel resource optimization scheme for multi-cellOFDMArelay network

Ning DU,Fa-sheng LIU

Journal Article

Transmission performance analysisof IR- UWB system in multipath environment

Lin Di,Sha Xuejun ,Wu Xuanli ,Zhang Naitong

Journal Article

Analyzing the Effect of the Intra-Pixel Position of Small PSFs for Optimizing the PL of Optical Subpixel

Haiyang Zhan, Fei Xing, Jingyu Bao, Ting Sun, Zhenzhen Chen, Zheng You, Li Yuan

Journal Article

Qin Ling: Articular Cartilage Tissue Engineering based on Functional Hydrogels (2022-7-24)

27 Jul 2022

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